New Mouse Model of Alzheimer’s

Immunogenicity of a New HIV-1 DNA Construct in a BALB/c Mouse Model

Background: Cell mediated immunity, especially cytotoxic T cell responses against HIV-1 infection, plays a critical role in controlling viral replication and disease progres-sion. DNA vaccine is a novel technology which is known to stimulate strong cellular immune responses. Many DNA vaccines have been tested for HIV infection but there is still no effective vaccine against this infection. Cons...

Quantification of Microtubule Stabilizing Drug Treatment effect on Axonal Transport Rate in a Transgenic Mouse Model of Alzheimers Disease

J. Kim, I-Y. Choi, M. L. Michaelis, and S-P. Lee Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, Neurology, University of Kansas Medical Center, Kansas City, KS, United States, Pharmacology & Toxicology, University of Kansas, Lawrence, KS, United States, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, U...

A new mouse model for Bartter's syndrome.

BARTTER’S SYNDROME (BS) COMPRISES a heterogeneous group of hereditary diseases, characterized by salt wasting, hypokalemia, and alkalosis, due to mutations in ion transport genes: the Na -K -2Cl cotransporter (NKCC2) and ROMK K channel in the apical membrane and the ClC-KB Cl channel in the basolateral membrane of thick ascending limb cells. A variant associated with sensorineural deafness (typ...

Current State of Alzheimers Disease Research Therapeutics

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Does Fungal Infection Cause Alzheimers?